Resource Type

Journal Article 34

Year

2023 2

2022 4

2021 4

2020 1

2019 2

2018 4

2017 1

2016 5

2013 1

2010 2

2009 2

2008 1

2007 1

2005 1

2004 1

open ︾

Keywords

immunity 6

innate immunity 3

plant immunity 3

active defense 2

active immunity 2

antiviral 2

inflammation 2

pathogenesis 2

Adaptive immune cells 1

Adenovirus serotype 5 1

Akkermansia muciniphila 1

Axin1 1

Bacteria 1

CD4+ and CD8+ T cells 1

Cell death 1

Cyclic lipopeptide 1

DNA vaccine 1

DNMT1 1

Development 1

E3 ubiquitin ligase 1

open ︾

Search scope:

排序： Display mode:

Toll-like receptors in innate immunity and infectious diseases

Min-Hao WU, Ping ZHANG, Xi HUANG,

Frontiers of Medicine 2010, Volume 4, Issue 4,   Pages 385-393 doi: 10.1007/s11684-010-0600-x

Abstract: primary response gene 88 (MyD88)-dependent or-independent signaling respectively, thereby modulating innateand adaptive immunity, as well as inflammatory responses.These studies of TLRs in the innate immune system have implications for the prevention and treatment

Keywords： Toll-like receptors     innate immunity     infectious disease     inflammation    

HTML PDF Collect

Critical roles of chemokines and cytokines in antiviral innate immune responses during rabies virus infection

Ying HUANG, Clement Wesley GNANADURAI, Zhenfang FU

Frontiers of Agricultural Science and Engineering 2017, Volume 4, Issue 3,   Pages 260-267 doi: 10.15302/J-FASE-2016116

Abstract: The innate immune response is the first line of defense against viral invasion and pro-inflammatory chemokinesand cytokines have a critical function in the innate immune responses against virus infections.In addition, recombinant RABV expressing cytokines and chemokines can induce elevated innate and adaptive

Keywords： antiviral     blood brain barrier     chemokines and cytokines     innate immunity     rabies virus    

HTML PDF Collect

Autoimmunity in acute ischemic stroke and the role of blood—brain barrier: the dark side or the light one?

Nikolay V. Tsygan, Alexandr P. Trashkov, Igor V. Litvinenko, Viktoriya A. Yakovleva, Alexandr V. Ryabtsev, Andrey G. Vasiliev, Leonid P. Churilov

Frontiers of Medicine 2019, Volume 13, Issue 4,   Pages 420-426 doi: 10.1007/s11684-019-0688-6

Abstract: The receptors of innate immunity (toll-like receptor-2 and toll-like receptor-4) are also involved in

Keywords： stroke     blood–brain barrier     autoimmunity     innate immunity     inflammation     cell death    

HTML PDF Collect

Innate immune responses in RNA viral infection

Qian Xu, Yuting Tang, Gang Huang

Frontiers of Medicine 2021, Volume 15, Issue 3,   Pages 333-346 doi: 10.1007/s11684-020-0776-7

Abstract: Upon viral invasion, the innate immune system responds rapidly and plays a key role in activating theIn the innate immune system, the interactions between pathogen-associated molecular patterns and hostMacrophages, dendritic cells, and natural killer cells are the principal innate immune components thatIn this review, the current understanding of innate immunity contributing to the restriction of RNA viralimmunity was discussed.

Keywords： innate immune     viral infection     intercellular signaling     metabolic changes     epigenetic changes    

HTML PDF Collect

Regulation of T cell immunity by cellular metabolism

Zhilin Hu, Qiang Zou, Bing Su

Frontiers of Medicine 2018, Volume 12, Issue 4,   Pages 463-472 doi: 10.1007/s11684-018-0668-2

Abstract:

T cells are an important adaptive immune response arm that mediates cell-mediated immunity.

Keywords： T cell immunity     metabolic pathways     nutrient uptake     metabolic checkpoints    

HTML PDF Collect

Innate immune checkpoint Siglec10 in cancers: mining of comprehensive omics data and validation in patient

Frontiers of Medicine 2022, Volume 16, Issue 4,   Pages 596-609 doi: 10.1007/s11684-021-0868-z

Abstract: Sialic acid binding Ig-like lectin 10 (Siglec10) is a member of innate immune checkpoints that inhibits

Keywords： innate immune checkpoint     Siglec10     kidney renal clear cell carcinoma    

HTML PDF Collect

Innate and adaptive T cells in influenza disease

Simone Nüssing, Sneha Sant, Marios Koutsakos, Kanta Subbarao, Thi H.O. Nguyen, Katherine Kedzierska

Frontiers of Medicine 2018, Volume 12, Issue 1,   Pages 34-47 doi: 10.1007/s11684-017-0606-8

Abstract: During natural infection, viral replication is initially controlled by innate immunity before adaptiveRecent studies also shed light on the role of innate T-cells (MAIT cells, gd T cells, and NKT cells)in controlling influenza and linking innate and adaptive immune mechanisms, thus making them attractiveWe summarize the current knowledge on influenza-specific innate MAIT and gd T cells as well as adaptivediscuss how these responses can be harnessed by novel vaccine strategies to elicit cross-protective immunity

Keywords： influenza     innate T cells     CD4+ and CD8+ T cells     vaccination    

HTML PDF Collect

Metabolism and immunity in breast cancer

Deyu Zhang, Xiaojie Xu, Qinong Ye

Frontiers of Medicine 2021, Volume 15, Issue 2,   Pages 178-207 doi: 10.1007/s11684-020-0793-6

Abstract: For tumor-associated immunity, poor immunogenicity and heightened immunosuppression cause breast cancer

Keywords： breast cancer     metabolism     immunity     cancer stem cells    

HTML PDF Collect

Rhizosphere immunity: targeting the underground for sustainable plant health management

Zhong WEI, Ville-Petri FRIMAN, Thomas POMMIER, Stefan GEISEN, Alexandre JOUSSET, Qirong SHEN

Frontiers of Agricultural Science and Engineering 2020, Volume 7, Issue 3,   Pages 317-328 doi: 10.15302/J-FASE-2020346

Abstract: Here we present the concept of rhizosphere immunity, in which plant health is considered as an ecosystemThese interactions can potentially extend the innate plant immune system to a point where the rhizosphereimmunity can fulfil all four core functions of a full immune system: pathogen prevention, recognition

Keywords： rhizosphere     soil microbiome     plant immunity     microbial ecology     plant health     soilborne pathogens    

HTML PDF Collect

Developmental Temporal Patterns and Molecular Network Features in the Transcriptome of Rat Spinal Cord Article

Jian Yang, Lili Zhao, Sheng Yi, Fei Ding, Yumin Yang, Yan Liu, Yongjun Wang, Mei Liu, Chengbin Xue, Lian Xu, Leilei Gong, Xinghui Wang, Yu Zhang, Bin Yu, Guo-li Ming, Xiaosong Gu

Engineering 2021, Volume 7, Issue 11,   Pages 1592-1602 doi: 10.1016/j.eng.2021.10.001

Abstract: Our study also supports the existence of a negative correlation between innate immunity and intrinsic

Keywords： Development     Gene expression pattern     Innate immunity     Spinal cord     Transcriptome    

HTML PDF Collect

Immunogenicity and protective immunity against otitis media caused by pneumococcus in mice of Hib conjugate

Zeyu Chen,Rong Guo,Jianghong Xu,Chuangjun Qiu

Frontiers of Medicine 2016, Volume 10, Issue 4,   Pages 490-498 doi: 10.1007/s11684-016-0470-y

Abstract:

This study evaluated the immunogenicity and protective immunity of a Hemophilus influenzaerate of pneumococcus and the inflammation of the middle ear showed the effectiveness of protective immunity

Keywords： conjugate vaccine     pneumococcal surface adhesin A     Hemophilus influenzae b     immunogenicity     otitis media    

HTML PDF Collect

Antitumor immunity of human SART3 gene vaccine against mouse tumor

HE Yu, YANG Shuhua, LIU Yong, LI Tao

Frontiers of Medicine 2008, Volume 2, Issue 1,   Pages 51-57 doi: 10.1007/s11684-008-0010-5

Abstract: whether squamous cell carcinoma antigen recognized by human T cell 3 (SART3) gene can induce antitumor immunityOne group was challenged with tumor cells after immunity.

Keywords： antitumor therapy     occurrence     implantation     DNA vaccine     SART3 DNA    

HTML PDF Collect

Decitabine induces -mediated immune responses in p53-mutated triple-negative breast cancer: a clinical and translational study

Frontiers of Medicine doi: 10.1007/s11684-023-1016-8

Abstract: DETECT trial, decitabine induced strong immune responses featuring the striking upregulation of the innate

Keywords： p53 mutation     triple-negative breast cancer     decitabine     DNMT1     IRF7     innate immune response    

HTML PDF Collect

HEMIPTERAN-TRANSMITTED PLANT VIRUSES: RESEARCH PROGRESS AND CONTROL STRATEGIES

Frontiers of Agricultural Science and Engineering 2022, Volume 9, Issue 1,   Pages 98-109 doi: 10.15302/J-FASE-2021389

Abstract: analyzes the key factors affecting insect transmission of plant viruses from the perspectives of insect immunity

Keywords： control strategies / feeding / immunity / insect vector / microorganism / plant virus    

HTML PDF Collect

Gut microbiota and its implications in small bowel transplantation

Chenyang Wang, Qiurong Li, Jieshou Li

Frontiers of Medicine 2018, Volume 12, Issue 3,   Pages 239-248 doi: 10.1007/s11684-018-0617-0

Abstract:

The gut microbiota is mainly composed of a diverse population of commensal bacterial species and plays a pivotal role in the maintenance of intestinal homeostasis, immune modulation and metabolism. The influence of the gut microbiota on solid organ transplantation has recently been recognized. In fact, several studies indicated that acute and chronic allograft rejection in small bowel transplantation (SBT) is closely associated with the alterations in microbial patterns in the gut. In this review, we focused on the recent findings regarding alterations in the microbiota following SBT and the potential roles of these alterations in the development of acute and chronic allograft rejection. We also reviewed important advances with respect to the interplays between the microbiota and host immune systems in SBT. Furthermore, we explored the potential of the gut microbiota as a microbial marker and/or therapeutic target for the predication and intervention of allograft rejection and chronic dysfunction. Given that current research on the gut microbiota has become increasingly sophisticated and comprehensive, large cohort studies employing metagenomic analysis and multivariate linkage should be designed for the characterization of host–microbe interaction and causality between microbiota alterations and clinical outcomes in SBT. The findings are expected to provide valuable insights into the role of gut microbiota in the development of allograft rejection and other transplant-related complications and introduce novel therapeutic targets and treatment approaches in clinical practice.

Keywords： gut microbiota     small bowel transplantation     acute rejection     chronic rejection     mucosal immunity     biomarker    

HTML PDF Collect

Title Author Date Type Operation

Toll-like receptors in innate immunity and infectious diseases

Min-Hao WU, Ping ZHANG, Xi HUANG,

Journal Article

Critical roles of chemokines and cytokines in antiviral innate immune responses during rabies virus infection

Ying HUANG, Clement Wesley GNANADURAI, Zhenfang FU

Journal Article

Autoimmunity in acute ischemic stroke and the role of blood—brain barrier: the dark side or the light one?

Nikolay V. Tsygan, Alexandr P. Trashkov, Igor V. Litvinenko, Viktoriya A. Yakovleva, Alexandr V. Ryabtsev, Andrey G. Vasiliev, Leonid P. Churilov

Journal Article

Innate immune responses in RNA viral infection

Qian Xu, Yuting Tang, Gang Huang

Journal Article

Regulation of T cell immunity by cellular metabolism

Zhilin Hu, Qiang Zou, Bing Su

Journal Article

Innate immune checkpoint Siglec10 in cancers: mining of comprehensive omics data and validation in patient

Journal Article

Innate and adaptive T cells in influenza disease

Simone Nüssing, Sneha Sant, Marios Koutsakos, Kanta Subbarao, Thi H.O. Nguyen, Katherine Kedzierska

Journal Article

Metabolism and immunity in breast cancer

Deyu Zhang, Xiaojie Xu, Qinong Ye

Journal Article

Rhizosphere immunity: targeting the underground for sustainable plant health management

Zhong WEI, Ville-Petri FRIMAN, Thomas POMMIER, Stefan GEISEN, Alexandre JOUSSET, Qirong SHEN

Journal Article

Developmental Temporal Patterns and Molecular Network Features in the Transcriptome of Rat Spinal Cord

Jian Yang, Lili Zhao, Sheng Yi, Fei Ding, Yumin Yang, Yan Liu, Yongjun Wang, Mei Liu, Chengbin Xue, Lian Xu, Leilei Gong, Xinghui Wang, Yu Zhang, Bin Yu, Guo-li Ming, Xiaosong Gu

Journal Article

Immunogenicity and protective immunity against otitis media caused by pneumococcus in mice of Hib conjugate

Zeyu Chen,Rong Guo,Jianghong Xu,Chuangjun Qiu

Journal Article

Antitumor immunity of human SART3 gene vaccine against mouse tumor

HE Yu, YANG Shuhua, LIU Yong, LI Tao

Journal Article

Decitabine induces -mediated immune responses in p53-mutated triple-negative breast cancer: a clinical and translational study

Journal Article

HEMIPTERAN-TRANSMITTED PLANT VIRUSES: RESEARCH PROGRESS AND CONTROL STRATEGIES

Journal Article

Gut microbiota and its implications in small bowel transplantation

Chenyang Wang, Qiurong Li, Jieshou Li

Journal Article